Clinical Chemistry

Using the latest analytical technology, we investigate a wide spectrum of parameters with low sample volumes. Using barcoding, samples are uniquely identified and are tracked during the entire process.

Special parameters/interface determination/therapeutic drug monitoring (TDM) are quantified with state-of-the-art analytical equipment:

High performance liquid chromatography with UV, fluorescence and electrochemical detection
High performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS)
Gas chromatography flame ionisation detection (GC-FID)
Gas chromatography mass spectrometry (GC/MS)
Atomic absorption spectrometry (AAS)
Electrospray ionization time-of-flight mass spectrometry (ESI-TOF)
Chromatographic separation techniques

Haematology

Under a medical specialist’s supervision, fully automated analytical equipment and experienced TA’s analyse microscopic differential blood counts and perform blood parasite diagnoses. This sample material (EDTA blood samples) is also used to quantify the biomarker HbA1c and blood sedimentation rate.

Coagulation

In addition to the routine parameters thromboplastin time (quick), partial thromboplastin time (PTT) and thrombin time (TT), we can analyse all special parameters, including heparin levels in urine.

Immunology

Testing of all relevant humoral hormones, tumour and biomarkers with high-throughput analysis by turbidity and electrochemiluminescence (ECL) methods.

Serology

This department examines human body fluids (mainly serum and cerebrospinal fluid) for all specific infection parameters, antibodies and autoantibodies, hormones and other immunological markers using methods such as ELISA, chemiluminescence, nephelometry and qualitative or quantitative PCR (DNA/RNA analysis). It specializes in the diagnosis of viruses, bacteria and autoimmune processes in order to assess the immune status and progression of diseases and provide important information for treatment.

Microbiology

This area offers a wide range of laboratory analyses based on isolation and identification of bacteria, fungi, viruses and parasites by microscopy, culture, ELISA (antigen detection), MALDI-TOF (matrix-assisted laser desorption/ionization time-of-flight mass spectrometry) and PCR. As required, bacteria and yeast resistance testing can follow.

Further Informations

Hygiene

We conduct investigations in the fields of hospital, food and water hygiene. Shipping materials (contact plates, swabs, bioindicators, sterile sample containers), request certificates, information on transport and storage of samples are provided. The spectrum includes:

Environmental studies/disinfection checks of surfaces using contact plates and swabs
Examination of water, bathing water and drinking water according to drinking water regulations (determining the bacterial count, E. coli and coliforms, Pseudomonas aeruginosa, Enterococci, among others.)
Examination of water for Legionella
Sovereignly trusted body for the examination on trichina
Using biological indicators, inspection of washing machines, disinfection equipment and sterilizers
Microbiological investigation of endoscopes and food

Further Informations

Molecular Biology/Cell Analytics

This department offers a wide range of methods (such as flow cytometry and Luminex multiplex assays) for analysing the structure, function, and behaviour of cells. Through flexible development and validation of new customer-specific analytical assays (e.g., for new biomarkers), the Cell Analysis Department offers tailor-made methods for preclinical research and clinical trials. SNP genotyping and gene expression can be decoded using modern NGS (next-generation sequencing) systems.

The following analyzers are available:

Luminex: multiplex analyses
- quantitative gene expression
- protein expression
Flow cytometer: cell analyses with up to ten parameters
Multimode plate reader: photometer with fluorescence and dispenser
- RNA/DNA/protein quantification
- ELISA
- single/dual luciferase assays (DLReady™)
- kinase assays (LanthaScreen™)
Real-time PCR system
- gene expression
- miRNA profiling
- SNP genotyping
- Pathogen detection
PCR devices
- Gene amplification
- cDNA synthesis
- Cloning
Gel electrophoresis systems: Separation or purification of RNA/DNA/proteins
Gel documentation device
- RNA/DNA/protein gels
- Western blots

Bioassays are highly individual and can be adapted as desired:

Antibody binding studies
In vitro toxicology:
- Eye/skin irritation/burns
- H-CLAT (human cell line activation test)
- MUSST (myeloid U937 skin sensitization test)
- KeratinoSens (in vitro skin sensitization test)
ADCC (antibody-dependent cell-mediated cytotoxicity), CDC (complement-mediated cytolysis)
Cell-based tests with neutralizing antibodies
Endotoxin measurements: LAL test, Interleukin-1β pyrogen test

Clinical Chemistry

Haematology

Coagulation

Immunology

Serology

Microbiology

Hygiene

Molecular Biology/Cell Analytics

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